Nutrition and Fasting
توضیحات
Maryam Amini
Ph.D. in Nutrition and diet therapy
Researcher of NationalNutrition and Food Technology Research Institute, Iran
admina
Fasting may offer numerous health advantages, such as weight reduction, improved blood sugar regulation, and a potential safeguard against various medical issues, including cancer and neurodegenerative diseases. Although it has gained significant attention in recent years, fasting is an ancient practice integral to numerous cultures and religions throughout history. Fasting is characterized by the voluntary abstention from certain foods or beverages for a designated duration, with various methods available.
Intermittent fasting, in particular, entails alternating between eating and fasting periods, which can last from several hours to a few days. The health benefits of fasting include enhanced weight loss and improved cognitive function. This discussion will first explore the scientifically supported health benefits of fasting, followed by an examination of the practice of fasting during Ramadan in Islam.
Benefits of Fasting

1. Extending Longevity
Numerous studies conducted on animals have yielded encouraging evidence regarding the potential of fasting to extend lifespan. A study from 2021 examined the effects of periodic fasting on the human gut and discovered that fasting enhanced the diversity of beneficial bacteria within the gut microbiome, notably including the Christensenella species, which are linked to increased longevity. The researchers also observed a rise in sirtuins, proteins that play a crucial role in metabolic regulation and are associated with longevity.
A review from the same year, encompassing both older human and animal research, corroborated these findings, indicating that fasting may effectively promote longevity and postpone the onset of disease. Nevertheless, further research is essential to elucidate the effects of fasting on longevity and aging in humans, as well as to identify the most effective fasting regimens.
2. Preventing Cancer
A review indicates that intermittent fasting may offer advantages in the treatment and prevention of cancer under certain circumstances. It has the potential to reduce tumor growth and mitigate the toxicity associated with chemotherapy for some individuals. However, the authors emphasize the necessity for more high-quality clinical trials and advise that individuals undergoing cancer treatment should only engage in intermittent fasting as part of a clinical trial.
In specific cases and for certain types of cancer, fasting could potentially have adverse effects. Additional reviews of in vitro and animal studies suggest that fasting may slow tumor progression and enhance the efficacy of chemotherapy. Despite these promising results, further investigations are required to explore how fasting may affect cancer development and treatment in humans.
3. Preventing Neurodegenerative Disorders
Although research primarily focuses on animal models, numerous studies indicate that fasting may significantly benefit brain health. Findings from animal studies suggest that fasting can safeguard brain function and promote the generation of new nerve cells, thereby enhancing cognitive abilities. Additionally, since fasting may alleviate inflammation, it could play a role in the prevention of neurodegenerative diseases. Specifically, research involving animals indicates that fasting might offer protection against and improve outcomes for conditions such as Alzheimer’s disease.
4. Combating Inflammation Combating Inflammation
Acute inflammation serves as a natural immune response to combat infections; however, chronic inflammation can have detrimental effects on health. This persistent inflammation may contribute to the onset of various chronic diseases, including heart disease, cancer, and rheumatoid arthritis. Research has shown that fasting can reduce inflammation levels, thereby fostering improved health.
5. Enhancing Insulin Sensitivity
Research has demonstrated that fasting may enhance blood sugar regulation, which is particularly beneficial for individuals at risk of developing diabetes. By reducing insulin resistance, fasting can improve the body’s responsiveness to insulin, facilitating the efficient transport of glucose from the bloodstream into cells. When combined with fasting’s potential to lower blood sugar levels, this effect may help maintain stable blood sugar, preventing fluctuations.
6. Advantages for Cardiovascular Health
Cardiovascular disease is recognized as the primary cause of mortality globally. Modifying your dietary habits and lifestyle represents one of the most effective strategies to mitigate the risk of heart disease. Some studies suggest that integrating fasting into your daily routine may offer particular advantages for cardiovascular health. A review indicated that alternate-day fasting could lower total cholesterol levels and various risk factors associated with heart disease in individuals with excess weight when compared to a control group. Additionally, another review demonstrated that alternate-day fasting could lead to significant reductions in blood pressure, as well as in blood triglycerides, total cholesterol, and LDL (low-density lipoprotein) cholesterol.
7. Enhancing Metabolic Rate
Numerous individuals on weight loss journeys experiment with fasting as a method to shed pounds. Theoretically, refraining from certain foods and beverages should lower overall caloric intake, potentially resulting in increased weight loss over time. An earlier review from 2015 indicated that whole-day fasting could lead to a reduction in body weight by as much as 9% and a significant decrease in body fat throuhout 12 to 24 weeks. Another review found that intermittent fasting was more effective for weight loss than continuous calorie restriction. Furthermore, additional research has indicated that fasting may result in more substantial reductions in body fat and abdominal fat compared to continuous calorie restriction.
8. Promoting Growth Hormone Secretion
Human growth hormone (HGH) is a protein hormone that plays a crucial role in various aspects of health. Research indicates that this vital hormone is integral to metabolism, weight management, and muscle development. Several studies have shown that fasting can naturally elevate HGH levels. One review article highlighted that fasting for 37.5 hours could increase basal HGH concentrations by up to tenfold.
Fasting Initiation Guide
There are various methods to engage in fasting, allowing individuals to select an approach that aligns with their lifestyle. It is advisable to explore different fasting techniques to determine which one is most suitable for you. Some common methods include water fasting, where only water is consumed for a designated duration; juice fasting, which involves the intake of only vegetable or fruit juices for a specific timeframe; and intermittent fasting, characterized by periods of partial or complete food restriction lasting from a few hours to several days, followed by a return to a regular diet on alternate days.
Partial fasting entails the exclusion of certain foods or beverages, such as processed items, animal products, or caffeine, for a predetermined period. Within these broader categories, there are also more specific fasting types. For instance, intermittent fasting can be further categorized into alternate-day fasting, where food is consumed every other day, and time-restricted feeding, which limits food intake to a few hours each day.
Fasting Safety and Considerations

Fasting may not be appropriate for everyone and can lead to adverse effects. For individuals with diabetes, fasting may result in dangerous fluctuations in blood sugar levels. It is advisable to consult a healthcare professional before initiating fasting, especially for those with pre-existing health conditions or those considering fasts exceeding 24 hours. Furthermore, fasting is generally not recommended without medical oversight for older adults, adolescents, individuals with low body weight, or those undergoing cancer treatment. Should you choose to fast, ensure adequate hydration and focus on consuming nutrient-rich foods during eating periods to enhance potential health benefits. Additionally, if engaging in prolonged fasting, it is prudent to limit vigorous physical activity and prioritize rest.
Fasting During Ramadan: Nutritional and Health Considerations

Fasting during Ramadan involves refraining from all food and beverages from dawn until dusk. Unlike other forms of fasting, consuming any liquids, including water, is prohibited during this period. Observers partake in two meals each day: the pre-dawn meal, referred to as “sahour,” and the meal that follows sunset, known as “iftar.” The limitation to two meals is primarily due to the restricted timeframe available for eating.
This period can facilitate meaningful changes in lifestyle choices, encouraging individuals to commit to healthier decisions, including those related to diet.
Physiological Changes During a Dawn-to-Dusk Fast
The body’s reaction to fasting is influenced by the duration of the fast. After the digestion and absorption of nutrients from the last meal, which typically takes eight to twelve hours, the body enters a fasting state and begins to utilize stored nutrients. Hormonal adjustments occur to facilitate access to these reserves, ensuring a steady supply of glucose.
For instance, insulin is a hormone that prompts cells to absorb and utilize glucose from the bloodstream. During fasting, insulin production decreases while anti-insulin hormones, such as glucagon and epinephrine, increase, enabling the body to tap into stored energy sources, including glycogen and fat, when food is not available. After approximately 24 hours, a healthy adult will deplete their stored glucose and start synthesizing new glucose by breaking down protein reserves, which may include muscle tissue.
Fasting from dawn until dusk during Ramadan provides a smooth and natural shift toward utilizing glycogen and fats for energy, thereby avoiding the negative effects of protein breakdown that are often linked to extended fasting periods.
Diet Composition and Weight Variations During Ramadan Fasting
The extensive cultural and geographical diversity among groups observing Ramadan, along with the resulting differences in fasting durations and dietary practices, complicates the ability to make generalized statements regarding alterations in body weight and diet composition during this period.
A primary alteration in dietary habits during Ramadan is the decrease in meal frequency. Nevertheless, numerous studies indicate that individuals typically do not lower their daily caloric intake during the fasting period.
Despite this, many fasting individuals experience a reduction in body weight and body fat. For instance, research involving young Jordanian women revealed no significant changes in caloric intake, macronutrient consumption, or overall physical activity levels during fasting; however, these women still experienced weight loss, a decrease in body mass index (BMI), and reductions in body water and body fat percentage.
Similarly, a study conducted on Malaysian men found that total caloric intake remained stable, even as protein and fat consumption increased, yet a decrease in waist-to-hip ratio was observed after 21 days of fasting. Notably, the most pronounced effects were seen in men of normal weight.
A recent analysis of various studies conducted across Asia, Africa, North America, and Europe assessing body weight changes during Ramadan indicated that fasting led to an average weight loss of approximately 3 pounds for both men and women.
The most significant weight loss was noted among East Asian populations, with a majority of the weight being regained within a few weeks following Ramadan. While populations in West and East Asia exhibited a reduction in daily caloric intake, African populations reported an increase in their daily caloric consumption during Ramadan. These fluctuations in caloric intake, whether increases or decreases, were linked to variations in carbohydrate consumption and were influenced by the culturally specific traditional foods consumed during this period.
Effects of Ramadan Fasting on Health Metabolic Indicators
A recent review highlights the positive impacts of fasting during Ramadan on various health markers related to cardiovascular risk, diabetes management, and kidney function.
Pregnancy and Fasting During Ramadan

Pregnant and lactating women are exempt from fasting during Ramadan. However, if a woman feels healthy and wishes to fast, particularly in the early stages of her pregnancy, she should seek guidance from her obstetrician to assess the safety of fasting. It is crucial to evaluate the effects of fasting on the developing fetus. Current research indicates that fasting, under the aforementioned circumstances, can be safely practiced by pregnant women.
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A study involving young pregnant Iranian women who fasted for an average of 13 days revealed no significant differences in the rates of low birth weight, pregnancy duration, or intrauterine growth among their infants. Furthermore, a larger comparative study of pregnant women who fasted versus those who did not found no notable differences in birth outcomes. Interestingly, the women who observed fasting exhibited lower rates of cesarean deliveries, although their infants had a reduced average birth weight.
Some limited epidemiological data suggest that adults whose fetal development occurred during Ramadan may exhibit lower weight and height. A recent population-based study compared Muslim adults whose fetal development coincided with Ramadan to those whose development did not. The findings indicated that individuals whose growth occurred during Ramadan tended to be thinner and shorter.
Physical Activity and Sports During Ramadan

Individuals who lead a sedentary lifestyle or engage in low to moderate intensity exercise can typically maintain their regular physical activity routines with minor modifications to the timing and intensity of their workouts. However, fasting presents a more complex challenge for competitive athletes. In addition to alterations in eating and hydration habits, fasting during Ramadan can lead to shifts in circadian rhythms, metabolism, and hormonal levels.
These physiological changes, coupled with potential sleep deprivation, can adversely affect athletic performance. Nevertheless, dedicated athletes can effectively manage their training during Ramadan with proper strategies.
During the fasting period of Ramadan, athletes may experience diminished performance and heightened fatigue. Research involving middle-distance runners who trained while fasting indicated a reduction in maximum aerobic velocity and an increase in fatigue levels.
Similarly, a study on adolescent soccer players revealed a decline in various performance metrics despite no changes in total caloric intake or sleep duration. Furthermore, the endurance capabilities of professional soccer players have also been shown to decline during Ramadan.
While there are both benefits and drawbacks to training at different times of the day, athletes can train effectively at any time with the right precautions. Evidence suggests that the optimal period for exercise, particularly for enhancing performance and maintaining body fat levels during intense aerobic activities, is in the evening after breaking the fast.
This timeframe coincides with peak physiological and psychomotor performance, and sufficient protein and carbohydrates are available to support positive protein balance and glycogen recovery. To mitigate the effects of fasting on training and athletic performance, athletes should prioritize adequate sleep, adjust their diets to ensure sufficient caloric, protein, and carbohydrate intake, and closely monitor for signs of chronic dehydration.
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Cardiovascular Health
Research indicates that fasting can lead to improvements in cardiovascular risk factors, particularly within the lipid profile. Evidence suggests a reduction in low-density lipoprotein (LDL) levels and an increase in high-density lipoprotein (HDL) levels during the fasting period. A comprehensive analysis of multiple studies revealed that total cholesterol and triglyceride levels decreased in men, while HDL levels increased in women throughout Ramadan fasting. Both genders experienced a decline in LDL cholesterol, indicating a lower risk for cardiovascular diseases.
Individuals predisposed to cardiovascular conditions demonstrated a notable enhancement in their 10-year risk for coronary heart disease after fasting for a minimum of 10 days during Ramadan. Generally, the favorable alterations in lipid profiles observed during fasting reverted to baseline levels several weeks following the conclusion of Ramadan.
Diabetes Management
Individuals with diabetes face heightened risks of both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) during fasting periods. Those requiring insulin for diabetes management are generally advised against fasting unless under medical supervision, which allows for appropriate monitoring and adjustments to insulin administration. It is essential to reschedule insulin delivery following the altered meal timings during Ramadan, and the use of an insulin pump is often recommended.
For individuals with diabetes who do not require insulin and maintain blood sugar control through diet or oral medications, consulting a physician before fasting is crucial, as adjustments to their medication regimen may be necessary due to the changes in eating patterns.
Research has indicated that fasting blood sugar levels, as well as postprandial blood sugar levels, tend to decrease among Type 2 diabetic patients during the month of Ramadan.
Glycemic control appears to show significant improvement during the month of Ramadan. Alongside better regulation of blood sugar levels, enhancements in lipid profiles and reductions in inflammatory markers have also been observed. While fasting blood sugar and lipid levels typically revert to their pre-fasting states a few weeks after the conclusion of Ramadan, the reduction in inflammatory markers tends to last for a more extended period.
For individuals with diabetes, it is advisable to practice moderation in carbohydrate and fat consumption during the evening meal, as well as to incorporate complex carbohydrates in the predawn meal. It is crucial for those with diabetes who intend to fast during Ramadan to seek guidance on medical, nutritional, and physical activity matters before commencing the fast. Furthermore, diabetics should be aware that if they encounter significant hypoglycemia while fasting, it is necessary to break the fast to manage the condition effectively.
Kidney Function
The complete abstention from food and fluids from dawn until dusk during Ramadan raises concerns regarding dehydration. Research indicates a reduction in total water consumption during this period. In response, the body adapts by lowering urine output and enhancing urine concentration. By the third week of Ramadan, the fluid deficit reaches its peak, although it is typically rectified by the conclusion of the month. This issue may be less pronounced in cooler and more humid environments.
If adequate measures are not taken to ensure rehydration during the hours when fasting is not observed, dehydration can become a significant health risk, potentially leading to severe consequences. Should serious symptoms of dehydration arise, such as dizziness, fatigue, muscle cramps, disorientation, or fainting, immediate action must be taken to replenish fluids and address the dehydration.
While the body’s need to concentrate urine increases during Ramadan, healthy individuals generally do not experience adverse effects on kidney function or urine output. However, there are concerns regarding the implications of fluid restriction for those with chronic kidney disease. Although findings are not definitive, some evidence suggests that fasting may lead to damage in renal tubular cells among individuals with chronic kidney disease.
Nevertheless, the positive effects of fasting on body weight, blood pressure, triglycerides, and glomerular filtration rate may outweigh the risks for individuals at various stages of chronic kidney disease. These individuals should consult a physician if they decide to observe the fast.
Fluid restriction may also affect those with a history of kidney stones, although the evidence remains inconclusive. Some studies have reported an increase in kidney stone formation during the initial weeks of Ramadan and a potential link between fasting and kidney stone development. Conversely, numerous other studies have found no such association. Individuals with a history of kidney stones who opt to fast during Ramadan should be particularly vigilant about their fluid intake and ensure they consume sufficient amounts.
Guidelines for a Healthy Ramadan

During the month of Ramadan, it is essential to prioritize adequate sleep, nutrition, and hydration while fasting. Many individuals experience delayed sleep onset and reduced deep sleep duration during this period, with over half of adults reporting decreased sleep quality. This lack of sufficient rest can adversely affect cognitive function in younger individuals and significantly hinder daytime productivity in adults, often more so than feelings of thirst or hunger. To mitigate these effects, it is advisable to minimize sleep disruptions and strive for high-quality sleep throughout Ramadan.
Maintaining a balanced diet that includes an appropriate intake of calories, vitamins, minerals, and fluids—particularly water—is crucial for preventing muscle breakdown, supporting physical activity, and avoiding dehydration.
The following are specific suggestions for foods to include in the suhoor and iftar meals:
Suhoor
This meal should be of moderate size; excessive consumption is unnecessary. It should be satisfying and consist of foods that provide sustained energy. Incorporating whole grains, proteins, fruits, vegetables, ample water, and healthy fats will aid in prolonging digestion and enhancing feelings of fullness.
Iftar
Traditionally, Iftar begins with dates, hot water, or thin tea. It is advisable to avoid cold water or chilled foods during this meal. A nutritious and balanced dinner should be consumed in the early evening, with no need for overeating.
Additional general recommendations include:

- Steering clear of heavily processed foods high in refined carbohydrates, fried items, and sugary or fatty pastries.
- Ensure adequate fluid intake, especially water, before bedtime to maintain proper hydration. Avoid thick tea.
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Final Thoughts
Fasting may offer various health advantages, such as weight reduction, enhanced blood sugar regulation, improved cardiovascular health, cognitive function, and potential cancer prevention. When combined with a balanced diet and a healthy lifestyle, these benefits may be further amplified.
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